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Kazusamycin B

Antitumor antibiotic
 
ALX-380-231-MC01 0.1 mg 525.00 USD
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Shows potent antitumor activity in vitro and in vivo against several tumor cell lines, including L1210 and P388 leukemia cells. Has antibacterial and antifungal activities. Inhibitor of nuclear export.

Product Specification

Alternative Name:Hydroxyleptomycin A, Antibiotic CL 1957E, PD 124,895
 
Formula:C32H46O7
 
MW:542.7
 
Source:Isolated from Streptomyces sp. MST-AS4898.
 
CAS:107140-30-7
 
RTECS:OA0551000
 
Purity:≥95% (HPLC)
 
Appearance:Colorless film.
 
Solubility:Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-231
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380-231

Product Literature References

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol. 4, 139 (1997), Abstract;
The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells: K. Takamiya, et al.; J. Antibiot. (Tokyo) 41, 1854 (1988), Abstract;
Antitumor effect of kazusamycin B on experimental tumors: E. Yoshida, et al.; J. Antibiot. (Tokyo) 40, 1596 (1987), Abstract;
Kazusamycin B, a novel antitumor antibiotic: K. Funaishi, et al.; J. Antibiot. (Tokyo) 40, 778 (1987), Abstract;
PD 124,895 and PD 124,966, two new antitumor antibiotics: T.R. Hurley, et al.; J. Antibiot. (Tokyo) 39, 1651 (1986), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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