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Venturicidin B

Mitochondrial ATP synthase complex inhibitor
ALX-380-223-MC25 0.25 mg 398.00 USD
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Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F0 membrane sector. Shows antifungal activity.

Product Specification

Alternative Name:Aabomycin A2
Source:Isolated from Streptomyces sp. MST-117594.
MI:14: 9947
Purity:≥95% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Long Term Storage:-20°C
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Product Literature References

Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC 203, 1005 (1994), Abstract;
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem. 268, 6158 (1993), Abstract; Full Text
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett. 249, 333 (1989), Abstract;
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985), Abstract;
Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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