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UCN-01

PKC and CDK inhibitor
 
ALX-380-222-MC25 0.25 mg 98.00 USD
 
ALX-380-222-M001 1 mg 387.00 USD
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Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.

Product Specification

Alternative Name:7-Hydroxystaurosporine
 
Formula:C28H26N4O4
 
MW:482.5
 
Source:Isolated from Streptomyces sp. MST-AS5345.
 
CAS:112953-11-4
 
RTECS:KC6600010
 
Purity:≥99% (HPLC)
 
Appearance:White film.
 
Solubility:Soluble in methanol, 100% ethanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Technical Info/Product Notes:Note: Some interconversion of UCN-01 to UCN-02 may occur under acidic HPLC conditions).
 
380-222
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380-222

Product Literature References

Dual roles of ERK1/2 in cellular senescence induced by excess thymidine in HeLa cells: I. Kudo, et al.; Exp. Cell. Res. 16, 30205 (2016), Application(s): Cell culture, cervical tumor, Abstract;
UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway: M.M. Facchinetti, et al.; Cancer Res. 64, 3629 (2004), Abstract; Full Text
UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?: S. Akinaga, et al.; Anticancer Drug Des. 15, 43 (2000), Abstract;
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line: K. Kawakami, et al.; BBRC 219, 778 (1996), Abstract;
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities: I. Takahashi, et al.; J. Antibiot. (Tokyo) 42, 571 (1989), Abstract;
UCN-01, a selective inhibitor of protein kinase C from Streptomyces: I. Takahashi, et al.; J. Antibiot. (Tokyo) 40, 1782 (1987), Abstract;

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