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VEGF inhibitor
ALX-380-221-M001 1 mg 189.00 USD
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Fungal metabolite found in a number of Aspergillus and Penicillium sp. Inhibitor of vascular endothelial growth factor (VEGF). Antiangiogenic agent. Inhibits eosinophil activation and chemotaxis.

Product Specification

Source:Isolated from Aspergillus terreus MST-FP1370.
Purity:≥99% (HPLC)
Appearance:Pale yellow solid.
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Long Term Storage:-20°C
Handling:Protect from light.
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Product Literature References

Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs: H.J. Lee, et al.; J. Antibiot. (Tokyo) 55, 552 (2002), Abstract;
Sulochrin inhibits eosinophil activation and chemotaxis: H. Ohashi, et al.; Inflamm. Res. 47, 409 (1998), Abstract;
Sulochrin inhibits eosinophil degranulation: H. Ohashi, et al.; J. Antibiot. (Tokyo) 50, 972 (1997), Abstract;
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol: A. Mahmoodian and C.E. Stickings; Biochem. J. 92, 369 (1964), Abstract; Full Text

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