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Sulochrin

VEGF inhibitor
 
ALX-380-221-M001 1 mg 185.00 USD
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Fungal metabolite found in a number of Aspergillus and Penicillium sp. Inhibitor of vascular endothelial growth factor (VEGF). Antiangiogenic agent. Inhibits eosinophil activation and chemotaxis.

Product Specification

Formula:C17H16O7
 
MW:332.3
 
Source:Isolated from Aspergillus terreus MST-FP1370.
 
CAS:519-57-3
 
Purity:≥99% (HPLC)
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
380-221
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380-221

Product Literature References

Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs: H.J. Lee, et al.; J. Antibiot. (Tokyo) 55, 552 (2002), Abstract;
Sulochrin inhibits eosinophil activation and chemotaxis: H. Ohashi, et al.; Inflamm. Res. 47, 409 (1998), Abstract;
Sulochrin inhibits eosinophil degranulation: H. Ohashi, et al.; J. Antibiot. (Tokyo) 50, 972 (1997), Abstract;
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol: A. Mahmoodian and C.E. Stickings; Biochem. J. 92, 369 (1964), Abstract; Full Text

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