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Elaiophylin

Inhibitor of testosterone 5-reductase and P-ATPase
 
ALX-380-212-M001 1 mg 317.00 USD
 
ALX-380-212-M005 5 mg 1,172.00 USD
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Macrolide antibiotic inhibiting testosterone 5-reductase and plasma-proton ATPase (P-ATPase). Shows antifungal, antiprotozoal, antitumor, antihelmintic and immunosuppressive activity.

Product Specification

Alternative Name:Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846 I, SNA 4606-3, Azalomycin B, Gopalamicin, Salbomycin
 
Formula:C54H88O18
 
MW:1025.3
 
Source:Isolated from Streptomyces sp. MT-1.
 
CAS:37318-06-2
 
RTECS:CL8380000
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Protect from light when in solution.
 
380-212
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380-212

Product Literature References

Time lapse imaging analysis of the effect of ER stress modulators on apoptotic cell assessed by caspase3/7 activation in NG108-15 cells: A. Saito, et al.; Data Brief 6, 20 (2015), Application(s): Cell culture, Abstract;
In vitro and in vivo antiprotozoal activities of bispolides and their derivatives: K. Otoguro, et al.; J. Antibiot. (Tokyo) 63, 275 (2010), Abstract;
Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes: P.A. Grigoriev, et al.; Bioelectrochemistry 54, 11 (2001), Abstract;
Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties.: C. Cui, et al.; Chinese J. Antibiot. 26, 165 (2001),
Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin: A. Fang, et al.; J. Antibiot. (Tokyo) 53, 158 (2000), Abstract;
SNA-4606-1, a new member of elaiophylins with enzyme inhibition activity against testosterone 5 alpha-reductase: M. Nakakoshi, et al.; J. Antibiot. (Tokyo) 52, 175 (1999), Abstract;
Elaiophylin as a rumen fermentation efficiency enhancer: C.M. Liu, et al.; J. Antibiot. (Tokyo) 46, 350 (1993), Abstract;
Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger: H.P. Fiedler, et al.; J. Antibiot. (Tokyo) 34, 1107 (1981), Abstract;
Melanosporin and elaiophylin, new antibiotics from Streptomyces malanosporus (sive melanosporofaciens) n. sp.: F.M. Arcamone, et al.; G. Microbiol. 7, 207 (1959),

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