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Venturicidin A

Inhibitor of mitochondrial ATP synthase
 
ALX-380-211-M001 1 mg 214.00 USD
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Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F0 membrane sector. Shows antifungal activity.

Product Specification

Alternative Name:Aabomycin A1
 
Formula:C41H67NO11
 
MW:750.0
 
Source:Isolated from Streptomyces sp. MST-117594.
 
CAS:33538-71-5
 
MI:14: 9947
 
RTECS:YX4556000
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-211
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380-211

Product Literature References

Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC 203, 1005 (1994), Abstract;
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem. 268, 6168 (1993), Abstract; Full Text
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett. 249, 333 (1989), Abstract;
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985), Abstract;
Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961), Abstract;

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