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Apoptolidin

F0F1-ATPase inhibitor
 
ALX-380-207-MC01 0.1 mg 283.00 USD
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Originally isolated from Nocardiopsis sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F0F1-ATPase inhibitor.

Product Specification

Formula:C58H96O21
 
MW:1129.4
 
Source:Isolated from Amicolatopsis sp. MST-AS5912.
 
CAS:194874-06-1
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-207
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380-207

Product Literature References

Apoptolidin: induction of apoptosis by a natural product: P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl. 45, 872 (2006), Abstract;
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues: P.A. Wender, et al.; Org. Lett. 8, 589 (2006), Abstract;
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase: A.R. Salomon, et al.; Chem. Biol. 8, 71 (2001), Abstract;
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase: A.R. Salomon, et al.; PNAS 97, 14766 (2000), Abstract; Full Text
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp: J.W. Kim, et al.; J. Antibiot. (Tokyo) 50, 6628 (1997), Abstract;

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