Apoptolidin

F₀F₁-ATPase inhibitor



ALX-380-207-MC01	0.1 mg	226.00 USD

Originally isolated from Nocardiopsis sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F₀F₁-ATPase inhibitor.

Product Specification

Formula:	C₅₈H₉₆O₂₁

MW:	1129.4

Purity:	≥95% (HPLC)

Appearance:	White to off-white solid.

CAS:	194874-06-1

Source/Host:	Isolated from Amicolatopsis sp. MST-AS5912.

Solubility:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.

Long Term Storage:	-20°C

Hazard:	HARMFUL.

Please mouse over

Product Literature References

Apoptolidin: induction of apoptosis by a natural product: P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl. 45, 872 (2006), Abstract;

Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues: P.A. Wender, et al.; Org. Lett. 8, 589 (2006), Abstract;

Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase: A.R. Salomon, et al.; Chem. Biol. 8, 71 (2001), Abstract; Full Text

Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase: A.R. Salomon, et al.; PNAS 97, 14766 (2000), Abstract; Full Text

Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp: J.W. Kim, et al.; J. Antibiot. (Tokyo) 50, 6628 (1997), Abstract;