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Simocyclinone D8

DNA gyrase inhibitor
 
ALX-380-153-M001 1 mg 246.00 USD
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Inhibitor of DNA Gyrase, Staphylococcus aureus (IC50= 1.45µM), E.coli (IC50= 0.41µM). Antibacterial (gram-positive). Antitumor.

Product Specification

Formula:C46H42ClNO18
 
MW:932.3
 
Source:Isolated from Streptomyces antibioticus.
 
CAS:301845-97-6
 
Purity:≥97% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO, dichloromethane, methanol, acetone or ethylacetate.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:After reconstitution protect from light at -20°C.
 
380-153
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380-153

Product Literature References

A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase: M.J. Edwards, et al.; Science 326, 1415 (2009), Abstract;
In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus: L.M. Oppegard, et al.; Antimicrob. Agents Chemother. 53, 2110 (2009), Abstract;
Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB: C. Sissi, et al.; Antimicrob. Agents Chemother. 54, 213 (2009), Abstract;
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action: R.H. Flatman, et al.; Antimicrob. Agents Chemother. 49, 1093 (2005), Abstract;
Biosynthesis of simocyclinone D8 in an 18O2-rich atmosphere: M. Holzenkämpfer & A. Zeeck; J. Antibiot. 55, 341 (2002), Abstract;
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 II. Structure elucidation and biosynthesis: M. Holzenkämpfer, et al.; J. Antibiot. 55, 301 (2002), Abstract;
Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040. I. Taxonomy, fermentation, isolation and biological activities: J. Schimana, et al.; J. Antibiot. 53, 779 (2000), Abstract;

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