Psicofuranine

Antitumor antibiotic



ALX-380-138-M001	1 mg	164.00 USD

ALX-380-138-M005	5 mg	654.00 USD

Nucleoside antibiotic. Antitumor compound. Inhibitor of xanthosine monophosphate (XMP) aminase. Antimetabolite within the purine biosynthesis.

Product Specification

Alternative Name:	Angustmycin C, U-9586, 9-β-D-Psicofuranosyl-9H-purin-6-amine

Identity:	Identity determined by ¹H-NMR and UV.

Formula:	C₁₁H₁₅N₅O₅

MW:	297.3

Purity:	≥98% (HPLC)

Appearance:	White to off-white solid.

CAS:	1874-54-0

MI:	14: 7923

Source/Host:	Isolated from Streptomyces sp.

Solubility:	Soluble in DMSO; poorly soluble in methanol.

Long Term Storage:	-20°C

Use/Stability:	Unstable against acids and bases.

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Product Literature References

Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase: G.A. McConkey; Exp. Parasitol. 94, 23 (2000), Abstract;

Role of purine biosynthetic intermediates in response to folate stress in Escherichia coli: C.E. Rohlman & R.G. Matthews; J. Bacteriol. 172, 7200 (1990), Abstract; Full Text

Nucleoside antibiotics: structure, biological activity, and biosynthesis: K. Isono; J. Antibiot. (Tokyo) 41, 1711 (1988), (Review), Abstract;

Formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5’-phosphate aminase and its inhibition by psicofuranine: T.T. Fukuyama; J. Biol. Chem. 241, 4745 (1966), Abstract; Full Text

Inhibition of Parental and Mutant Xanthosine 5’-Phosphate Aminases by Psicofuranine: S. Udaka & H.S. Moyed; J. Biol. Chem. 238, 2797 (1963), Abstract; Full Text

Mechanism of action of psicofuranine: L.J. Hanka; J. Bacteriol. 80, 30 (1960), Abstract; Full Text

Psicofuranine I. Discovery, isolation, and properties: T.E. Eble, et al.; Antibiot. Chemother. 9, 419 (1959),

Psicofuranine. VI. Antitumor and toxicopathological studies: J.S. Evans & J.E. Gray; Antibiot. Chemother. 9, 675 (1959), Abstract;

Studies on angustmycins VIII. The structure of angustmycin C: H. Yüntsen; J. Antibiot. (Tokyo) 11A, 244 (1958),