Pyridone metabolite. Inhibitor of nitric oxide synthases (NOS) showing selectivity for eNOS (NOS III) versus nNOS (NOS I). Inhibitor of thaxtomine biosynthesis and of mitochondrial electron transport chain.
Product Specification
| Alternative Name: | 6-(3,7-Dimethyl-octa-2,5-dienyl)-4-hydroxy-3-methyl-5-propyl-1H-pyridin-2-one |
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| Formula: | C19H29NO2 |
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| MW: | 303.5 |
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| Source: | Isolated from Streptomyces bottropensis. |
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| CAS: | 213137-53-2 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Off-white to greenish solid. |
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| Solubility: | Soluble in DMSO; fairly soluble in methanol; poorly soluble in acetone. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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Product Literature References
Iromycins from Streptomyces sp. and from synthesis: New inhibitors of the mitochondrial electron transport chain: F. Surup, et al.; Bioorg. Med. Chem.
16, 1738 (2008),
Abstract;
Iromycins: a new family of pyridone metabolites from Streptomyces sp. II. Convergent total synthesis: H. Shojaei, et al.; J. Org. Chem.
72, 5091 (2007),
Abstract;
The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis: F. Surup, et al; J. Org. Chem.
72, 5085 (2007),
Abstract;
