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Iromycin A

NOS inhibitor



ALX-380-124-M001	1 mg	668.00 USD
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Pyridone metabolite. Inhibitor of nitric oxide synthases (NOS) showing selectivity for eNOS (NOS III) versus nNOS (NOS I). Inhibitor of thaxtomine biosynthesis and of mitochondrial electron transport chain.

Product Specification

Alternative Name:	6-(3,7-Dimethyl-octa-2,5-dienyl)-4-hydroxy-3-methyl-5-propyl-1H-pyridin-2-one

Formula:	C₁₉H₂₉NO₂

MW:	303.5

Source:	Isolated from Streptomyces bottropensis.

CAS:	213137-53-2

Purity:	≥98% (HPLC)

Identity:	Determined by ¹H-NMR.

Appearance:	Off-white to greenish solid.

Solubility:	Soluble in DMSO; fairly soluble in methanol; poorly soluble in acetone.

Shipping:	Ambient

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Handling:	After reconstitution protect from light at -20°C.

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Product Literature References

Iromycins from Streptomyces sp. and from synthesis: New inhibitors of the mitochondrial electron transport chain: F. Surup, et al.; Bioorg. Med. Chem. 16, 1738 (2008), Abstract;

Iromycins: a new family of pyridone metabolites from Streptomyces sp. II. Convergent total synthesis: H. Shojaei, et al.; J. Org. Chem. 72, 5091 (2007), Abstract;

The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis: F. Surup, et al; J. Org. Chem. 72, 5085 (2007), Abstract;