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Minocycline . hydrochloride

PARP-1 inhibitor
 
ALX-380-109-M050 50 mg 40.00 USD
 
Tetracycline derivative with antimicrobial activity. Inhibitor of angiogenesis, apoptosis and poly(ADP-ribose) polymerase-1 (PARP-1).
MMP inhibitor.
Anti-inflammatory and neuroprotective.

Product Specification

Alternative Name:Dynacin, Klinomycin, Minocin, Vectrin
 
Formula:C23H27N3O7 . HCl
 
MW:457.5 . 36.5
 
Source:Semisynthetic.
 
CAS:13614-98-7
 
MI:14: 6202
 
RTECS:QI7630500
 
Purity:≥98% (UHPLC)
 
Appearance:Yellow crystalline solid.
 
Solubility:Soluble in water (50mg/ml, warm) or DMSO (7mg/ml).
 
Long Term Storage:-20°C
 
380-109
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380-109

Product Literature References

Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice: C.H. Park, et al.; Korean J. Physiol. Pharmacol. 15, 115 (2011), Abstract;
Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration: J.S. Yao, et al.; Neurochem. Int. 50, 524 (2007), Abstract;
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia: Y. Levkovitz, et al.; Brain Res. 1154, 154 (2007), Abstract;
Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation: K. Maier, et al.; Neurobiol. Dis. 25, 514 (2007), Abstract;
Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations: C.C. Alano, et al.; PNAS 103, 9685 (2006), Abstract;
Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy: J.K. Krady, et al.; Diabetes 54, 1559 (2005), Abstract;
Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis: M. Castanares, et al.; BBRC 337, 663 (2005), Abstract;
Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases: J.S. Yao, et al.; Circ. Res. 95, 364 (2004), Abstract;
Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria: J. Wang, et al.; J. Biol. Chem. 279, 19948 (2004), Abstract;
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma: J.L. Frazier, et al.; J. Neurooncol. 64, 203 (2003), Abstract;

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