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Leptomycin A

Nuclear export inhibitor
 
ALX-380-101-C050 50 µg 55.00 USD
 
ALX-380-101-C100 100 µg 87.00 USD
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Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA.

Product Specification

Alternative Name:ATS1287 A, LMA
 
Formula:C32H46O6
 
MW:526.7
 
Source:Isolated from Streptomyces sp.
 
CAS:87081-36-5
 
Concentration:0.1mg/ml
 
Purity:≥95% (HPLC)
 
Identity:Identity determined by MS.
 
Appearance:Liquid. In 100% ethanol.
 
Solubility:Soluble in methanol or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas.
 
380-101
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380-101

Product Literature References

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization: T. Hamamoto, et al.; J Antibiot (Tokyo) 36, 639 (1983), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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