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Concanamycin C

V-ATPase inhibitor
 
ALX-380-099-C500 500 µg 2,580.00 USD
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Antibiotic. Inhibits vacuolar-type H+-ATPase. Potential antiosteoporotic agent. Shows antiviral and immunosuppressive activity. Active against fungi and yeasts.

Product Specification

Formula:C45H74O13
 
MW:823.1
 
Source:Isolated from Streptomyces sp.
 
CAS:81552-34-3
 
RTECS:GK6887000
 
Purity:≥96% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:After reconstitution protect from light at -20°C.
 
380-099
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380-099

Product Literature References

Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes: S. Drose, et al.; Biochemistry 40, 2816 (2001), Abstract;
Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa: E.J. Bowman, et al.; J. Biol. Chem. 275, 167 (2000), Abstract;
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993), Abstract;
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984), Abstract;
Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 35, 1618 (1982), Abstract;

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