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Netropsin . dihydrochloride

Nucleic acid binding ligand
 
ALX-380-088-M005 5 mg 53.00 USD
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Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.

Product Specification

Alternative Name:4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
 
Formula:C18H26N10O3 . 2HCl
 
MW:430.5 . 73.0
 
Source:Isolated from Streptomyces netropsis.
 
CAS:1438-30-8
 
RTECS:DW2973000
 
Purity:≥90% (HPLC)
 
Appearance:Faint yellow powder.
 
Solubility:Soluble in alcohols or water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
380-088
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380-088

Product Literature References

Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem. 8, 475 (2001), (Review), Abstract;
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol. 47, 855 (2000), Abstract;
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry 38, 16067 (1999), Abstract;
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985),
Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951),

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