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Antimycin A

Antibiotic
 
ALX-380-075-M005 5 mg 34.00 USD
 
ALX-380-075-M010 10 mg 41.00 USD
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Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.

Product Specification

Alternative Name:Antipiricullin, Virosin
 
Source:Isolated from Streptomyces sp. Mixture of antimycin A's.
 
CAS:1397-94-0
 
MI:14: 714 (A1) & 715 (A3)
 
RTECS:CD0350000
 
Purity:≥90% (HPLC)
 
Appearance:White to faint yellow powder.
 
Solubility:Soluble in 100% ethanol (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
ALX-380-075
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ALX-380-075

Product Literature References

The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells: B. Plitzko, et al.; J. Biol. Chem. (2017), Abstract; Full Text
The effect of phosphate availability on chondrocyte metabolic function: K. Blank, et al.; (2016), (master's thesis), Application(s): Inhibitor of complex III in the electron transport chain, Full Text
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007), Abstract;
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004), Abstract;
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol. 3, 183 (2001), Abstract;
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001), Abstract;
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001), Abstract;
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract;
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992), Abstract; Full Text
The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949),

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For Research Use Only. Not for use in diagnostic procedures.
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