Antimycin A

Antibiotic



ALX-380-075-M005	5 mg	22.00 USD

ALX-380-075-M010	10 mg	35.00 USD

Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.

Product Specification

Alternative Name:	Antipiricullin, Virosin

Purity:	≥95% (HPLC)

Appearance:	White to faint yellow powder.

CAS:	1397-94-0

MI:	14: 714 (A1) & 715 (A3)

RTECS:	CD0350000

Source/Host:	Isolated from Streptomyces sp. Mixture of antimycin A's.

Solubility:	Soluble in 100% ethanol (50mg/ml).

Long Term Storage:	-20°C

Hazard:	TOXIC.

Handling:	Protect from light.

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Product Literature References

An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007), Abstract;

Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004), Abstract;

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol. 3, 183 (2001), Abstract;

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001), Abstract;

Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001), Abstract;

Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract;

The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992), Abstract; Full Text

The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949),