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WP631 . dimethanesulfonate

Fluorescent bisintercalating anthracycline antibiotic
ALX-380-074-C500 500 µg 182.00 USD
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Synthetic fluorescent bisintercalating anthracycline antibiotic with ultratight binding properties to DNA. Inhibits Sp1-initiated transcription at nanomolar concentrations. Appears to overcome multidrug resistance protein (MRP) mediated multidrug resistance (MDR). More water soluble than WP631 . dihydrochloride. Licenced product covered by US Patent 5,874,412. Sold with permission of Houston Pharmaceuticals, Inc.

Product Specification

Formula:C62H64N2O20 . 2CH3SO3
MW:1157.2 . 191.2
Purity:≥95% (TLC, single spot)
Identity:Determined by MS and NMR.
Appearance:Red powder.
Solubility:Soluble in DMSO (10mg/ml) or water (1mg/ml).
Long Term Storage:-20°C
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Product Literature References

Sequence selective binding of bis-daunorubicin WP631 to DNA: K.R. Fox, et al.; Eur. J. Biochem. 271, 3556 (2004), Abstract;
Inhibition of basal and transforming growth factor-beta-induced stimulation of COL1A1 transcription by the DNA intercalators, mitoxantrone and WP631, in cultured human dermal fibroblasts: S. Gaidarova and S.A. Jimenez; J. Biol. Chem. 277, 38737 (2002), Abstract;
Analysis of the effects of daunorubicin and WP631 on transcription: J. Portugal, et al.; Curr. Med. Chem. 8, 1 (2001), Abstract;
Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro: B. Martin, et al.; Nucleic Acids Res. 27, 3402 (1999), Abstract;
Drug-DNA interactions: J.B. Chaires; Curr. Opin. Struct. Biol. 8, 314 (1998), Abstract;
Ultratight DNA binding of a new bisintercalating anthracycline antibiotic: F. Leng, et al.; Biochemistry 37, 1743 (1998), Abstract;
Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy: H. Robinson, et al.; Biochemistry 36, 8663 (1997), Abstract;
Structure of a DNA-bisdaunomycin complex: G.G. Hu, et al.; Biochemistry 36, 5940 (1997), Abstract;
Structure-based design of a new bisintercalating anthracycline antibiotic: J.B. Chaires, et al.; J. Med. Chem. 40, 261 (1997), Abstract;

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