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Chartreusin

Antitumor antibiotic
 
ALX-380-073-M025 25 mg 763.00 USD
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Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents.

Product Specification

Alternative Name:Lambdamycin
 
Formula:C32H32O14
 
MW:640.6
 
Source:Isolated from Streptomyces chartreusis.
 
CAS:6377-18-0
 
MI:14: 2045
 
RTECS:FL7350000
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in acetone; insoluble in water.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at +4°C.
 
Handling:After reconstitution protect from light at -20°C.
 
ALX-380-073 structure
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ALX-380-073 structure

Product Literature References

Chartreusin, elsamicin A and related anti-cancer antibiotics: J. Portugal; Curr. Med. Chem. Anticancer Agents 3, 411 (2003), Review, Abstract;
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer 14, 1985 (1993), Abstract;
Chartreusin, a glycosidic antitumour antibiotic from Streptomyces: J.A. Beisler; Prog. Med. Chem. 19, 247 (1982), (Review), Abstract;
Chartreusin, a New Antibiotic Produced by Streptomyces chartreusis, a New Species: B. E. Leach, et al.; J. Am. Chem. Soc. 75, 4011 (1953),

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Topoisomerase
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Topoisomerase Inhibitor
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