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Bacterial DNA-dependent RNA polymerase inhibitor
ALX-380-071-M100 100 mg 34.00 USD
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Replaces Prod. #: BML-GR306

A selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Has no effect on mammalian RNA polymerase. The RNAP-rifampicin complex locks the promoter in an abortive initiation reaction making short oligoribonucleotides which diffuse out of the active site. Inhibits α-synuclein fibrillation and disaggregates fibrils. Potent inducer of hepatic cytochrome P450 enzymes.

Product Specification

Alternative Name:Rifampin, 3-(4-Methylpiperazinyl-iminomethyl)rifamycin SV
MI:14: 8216
Purity:≥97% (Assay)
Appearance:Orange to brown powder.
Solubility:Soluble in DMSO (25mg/ml) or methanol (25mg/ml).
Long Term Storage:-20°C
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Product Literature References

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor: J. Chen and K. Raymond; Ann. Clin. Microbiol. Antimicrob. 50, 3 (2006), Review, Abstract;
Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils: J. Li, et al.; Chem. Biol. 11, 1513 (2004), Abstract;
Pharmacokinetic interactions with rifampicin : clinical relevance: M. Niemi, et al.; Clin. Pharmacokinet. 42, 819 (2003), Review, Abstract;
Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase: K. Severinov, et al.; J. Biol. Chem. 268, 14820 (1993), Abstract;
Pharmacokinetic drug interactions with rifampicin: K. Venkatesan; Clin. Pharmacokinet. 22, 47 (1992), Review, Abstract;
On the mechanism of rifampicin inhibition of RNA synthesis: W.R. McClure and C.L. Cech; J. Biol. Chem. 253, 8949 (1978), Abstract;
Chemical and biological properties of rifampicin: S. Furesz; Antibiot. Chemother. 16, 316 (1970), Abstract;
Rifampicin sensitivity of the components of DNA-dependent RNA polymerase: E. di Mauro, et al.; Nature 222, 533 (1969), Abstract;
Rifampicin: a new orally active rifamycin: N. Maggi, et al.; Chemotherapy 11, 285 (1966), Abstract;

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