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β-Rubromycin

Inhibitor of HIV-1 reverse transcriptase and human telomerase
 
ALX-380-067-M001 1 mg 191.00 USD
 
ALX-380-067-M005 5 mg 763.00 USD
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Antibiotic. Inhibitor of HIV-1 reverse transcriptase (RT). Inhibits human telomerase. Cytostatically active against different tumor cell lines.

Product Specification

Formula:C27H20O12
 
MW:536.5
 
Source:Isolated from Streptomyces sp.
 
CAS:27267-70-5
 
Purity:≥99%
 
Solubility:Soluble in chloroform.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-067
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380-067

Product Literature References

Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000), Abstract;
Structural and Biosynthetic Investigations of the Rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000),
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990), Abstract;
Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 1709 (1970), Abstract;
Rubromycin II: H. Brockmann, et al.; Chem. Ber. 102, 126 (1969), Abstract;
The structure of rubromycin: H. Brockmann, et al.; THL 30, 3525 (1966), (Article in German), Abstract;

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