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Kendomycin

Endothelin receptor antagonist
 
ALX-380-066-C500 500 µg 654.00 USD
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Potent endothelin receptor antagonist. Anti-osteoporotic compound. Shows remarkable antibacterial and cytotoxic activity. Mediates its cytotoxic effects, at least in part, through proteasome inhibition.

Product Specification

Alternative Name:(-)-TAN 2162
 
Formula:C29H42O6
 
MW:486.6
 
Source:Isolated from Streptomyces violaceoruber.
 
CAS:183202-73-5
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Yellow powder.
 
Solubility:Slightly soluble in DMSO or methanol.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:After reconstitution protect from light at -20°C.
 
ALX-380-066
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ALX-380-066

Product Literature References

Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; Chembiochem. 8, 1261 (2007), Abstract;
Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: A.Zeeck & H.B. Bode; J. Chem. Soc. Perkin Trans. 323 (2000),

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For Research Use Only. Not for use in diagnostic procedures.
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