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Daunorubicin . hydrochloride

Antitumor antibiotic
ALX-380-043-M010 10 mg 106.00 USD
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Replaces Prod. #: BML-GR318

Anthracycline anticancer antibiotic. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase I and II. Inhibits RNA and DNA synthesis. Induces DNA single strand breaks and apoptosis in tumor cells.

Product Specification

Alternative Name:Daunomycin . HCl
Formula:C27H29NO10 . HCl
MW:527.5 . 36.5
Source:Isolated from Streptomyces spec.
MI:14: 2832
Appearance:Orange to red crystalline powder.
Activity:≥842 µg/mg
Solubility:Soluble in water or methanol.
Long Term Storage:-20°C
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Product Literature References

PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text
Signaling pathways activated by daunorubicin:: G. Laurent & J. P. Jaffrezou; Blood 98, 913 (2001), Review, Abstract;
Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells: J. Chen, et al.; Biochim. Biophys. Acta. 1488, 219 (2000), Abstract;
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin: D.A. Gewirtz; Biochem. Pharmacol. 57, 727 (1999), Abstract;
Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: influence of drug transport abnormalities: M.G. Come, et al.; Int. J. Cancer 81, 580 (1999), Abstract;
Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia: X.F. Hu, et al.; Blood 93, 4086 (1999), Abstract;
Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells: K.J. Turnbull, et al.; Leukemia 13, 1056 (1999), Abstract;
Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis: A. Bettaieb, et al.; Mol. Pharmacol. 55, 118 (1999), Abstract;
Implication of radical oxygen species in ceramide generation, c-Jun N- terminal kinase activation and apoptosis induced by daunorubicin: V. Mansat-de Mas, et al.; Mol. Pharmacol. 56, 867 (1999), Abstract;
The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines: I. Plo, et al.; FEBS Lett 452, 150 (1999), Abstract;
Characterization of covalent adriamycin-DNA adducts: S.M. Zeman, et al.; PNAS 95, 11561 (1998), Abstract;
Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells: M.P. Boland, et al.; J. Biol. Chem. 272, 12952 (1997), Abstract; Full Text
Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin: D.J. Taatjes, et al.; J. Med. Chem. 39, 4135 (1996), Abstract;
Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals: R. Bose, et al.; Cell 82, 405 (1995), Abstract;

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