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Polymyxin B . sulfate

PKC inhibitor
ALX-380-040-G001 1 g 69.00 USD
ALX-380-040-G005 5 g 246.00 USD
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Antibiotic. Inhibitor of protein kinase C (PKC). Breaks the bacterial membrane by incorporating into the phospholipid of the outer membrane and activating phospholipase.

Product Specification

MI:14: 7573
Purity:≥80% (HPLC) (sum of polymyxins B1, B2, B3, B1-I)
Purity Detail:Mixture of Polymyxin B1, B2, B3 and B1-I.
Appearance:White to off-white powder.
Solubility:Soluble in water (50mg/ml).
Long Term Storage:+4°C
Polymyxin B1
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Product Literature References

Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule: D. Ferrari, et al.; Br. J. Pharmacol. 150, 445 (2007), Abstract;
Polymyxin antibiotics for gram-negative infections: T. M. Arnold, et al.; Am. J. Health Syst. Pharm. 64, 819 (2007), Review, Abstract;
Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion: B. Valentinis, et al.; J. Biol. Chem. 280, 14264 (2005), Abstract;
Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells: A. Ngezahayo & H.A. Kolb; Pfluegers Arch. 422, 413 (1993), Abstract;
Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action: A. Guma, et al.; Biosci. Rep. 12, 413 (1992), Abstract;
Volume-regulatory Cl- channel currents in cultured human epithelial cells: M. Kubo & Y. Okada; J. Physiol. 456, 351 (1992), Abstract;
Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B & cardiotoxin. Differential inhibition of PKC, CaMKII & synaptosomal membrane Na,K-ATPase & Na+ pump & differentiation of HL60 cells.: R.L. Raynor, et al.; J. Biol. Chem. 266, 2753 (1991), Abstract; Full Text
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine: C. Schächtele, et al.; BBRC 151, 542 (1988), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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