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Oligomycin C

F-ATPase inhibitor
 
ALX-380-039-M001 1 mg 410.00 USD
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Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis.

Product Specification

Alternative Name:12-Deoxyoligomycin A
 
Formula:C45H74O10
 
MW:775.1
 
Source:Isolated from Streptomyces sp. MST-AS5339.
 
CAS:11052-72-5
 
MI:14: 6833
 
RTECS:RK3335000
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
380-039
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380-039

Product Literature References

Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004), Abstract;
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002), Abstract; Full Text
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000), Abstract; Full Text
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Engr. 2, 31 (1960), Abstract;

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