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Oligomycin

F-ATPase inhibitor
 
ALX-380-037-M005 5 mg 83.00 USD
 
ALX-380-037-M010 10 mg 143.00 USD
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Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis.

Product Specification

MW:789.3
 
Source:Isolated from Streptomyces diastatochromogens.
 
CAS:1404-19-9
 
MI:14: 6833
 
RTECS:RK3325000
 
Purity:≥90% (mixture of oligomycin A, B, and C) (HPLC, TLC)
 
Appearance:White to faint yellow powder.
 
Solubility:Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
380-037
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380-037

Product Literature References

The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions: S. Koob, et al.; Biochim. Biophys. Acta 1853, 1551 (2015), Application(s): Cell Culture, Abstract;
Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions: R. Dawaliby, et al.; Mol. Biol. Cell 21, 4173 (2010), Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000), Abstract;
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000), Abstract;
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998), Abstract; Full Text
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994), Abstract;
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993), Abstract;
Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993), Abstract;
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993), Abstract;

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