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Neomycin . sulfate

Inhibitor of PLC and PLD
ALX-380-035-G025 25 g 32.00 USD
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Replaces Prod. #: BML-EI180

Aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Inhibitor of phospholipase C (PLC; IC50=1-10µM) due to binding to inositol phospholipids. Neomycin inhibits phosphatidylcholine-phospholipase D activity (IC50=65µM). Blocks voltage sensitive Ca2+ channels without affecting Na+/Ca2+ antiporters in nerve cells. Induces PLA2 activation in human platelets.

Product Specification

Formula:C23H46N6O13 . 3H2SO4
MW:614.7 . 294.2
MI:14: 6454
Appearance:White to off-white solid.
Activity:Potency is ≥ 650 IU/mg (on dry basis).
E. coli
growth inhibition ED50 ≤ 20 µg/ml.
Solubility:Soluble in water (10mg/ml).
Long Term Storage:+4°C
Handling:Protect from light and moisture.
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Product Literature References

Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores: P. Sobolewski, et al.; Am. J. Physiol. Cell Physiol. 301, C679 (2011), Abstract;
Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells: G.R. Hammond, et al.; J. Cell Sci. 119, 2084 (2006), Abstract; Full Text
Neomycin inhibits glioma cell migration: P. Cuevas, et al.; Neurol. Res. 26, 273 (2004), Abstract;
Antiproliferative action of neomycin is associated with inhibition of cyclin D1 activation in glioma cells: P. Cuevas, et al.; Neurol. Res. 25, 961 (2003), Abstract;
Nerve extracts and substance P activate the phosphatidylinositol signaling pathway and mitogenesis in newt forelimb regenerates: M.J. Smith, et al.; Dev. Biol. 167, 239 (1995), Abstract;
Neomycin inhibition of hormone-stimulated smooth muscle contractions in myometrial tissue: M. Philippe; BBRC 205, 245 (1994), Abstract;
Gadolinium and neomycin block voltage-sensitive Ca2+ channels without interfering with the Na(+)-Ca2+ antiporter in brain nerve endings: L.M. Canzoniero, et al.; Eur. J. Pharmacol. 245, 97 (1993), Abstract;
Inhibition of neural phospholipase D activity by aminoglycoside antibiotics: M. Liscovitch, et al.; Biochem. J. 279, 319 (1991), Abstract;
Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2): E. Gabev, et al.; Biochim. Biophys. Acta 979, 105 (1989), Abstract;
Neomycin is a potent agent for arachidonic acid release in human platelets: S. Nakashima, et al.; BBRC 146, 820 (1987), Abstract;
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation- contraction coupling in muscle: J. Vergara, et al.; PNAS 82, 6352 (1985), Abstract;
Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation: D.H. Carney, et al.; Cell 42, 479 (1985), Abstract;
Effects of neomycin on calcium and polyphosphoinositide metabolism of guinea pig synaptosomes: H.D. Griffin, et al.; J. Neurochem. 34, 750 (1980), Abstract;

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