Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Neomycin . sulfate

Inhibitor of PLC and PLD
 
ALX-380-035-G025 25 g 34.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-EI180

Aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Inhibitor of phospholipase C (PLC; IC50=1-10µM) due to binding to inositol phospholipids. Neomycin inhibits phosphatidylcholine-phospholipase D activity (IC50=65µM). Blocks voltage sensitive Ca2+ channels without affecting Na+/Ca2+ antiporters in nerve cells. Induces PLA2 activation in human platelets.

Product Specification

Formula:C23H46N6O13 . 3H2SO4
 
MW:614.7 . 294.2
 
CAS:1405-10-3
 
MI:14: 6454
 
RTECS:QP4375000
 
Appearance:White to off-white solid.
 
Activity:Potency is ≥ 650 IU/mg (on dry basis).
E. coli
growth inhibition ED50 ≤ 20 µg/ml.
 
Solubility:Soluble in water (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
ALX-380-035
Please mouse over
ALX-380-035

Product Literature References

Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores: P. Sobolewski, et al.; Am. J. Physiol. Cell Physiol. 301, C679 (2011), Abstract;
Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells: G.R. Hammond, et al.; J. Cell Sci. 119, 2084 (2006), Abstract; Full Text
Neomycin inhibits glioma cell migration: P. Cuevas, et al.; Neurol. Res. 26, 273 (2004), Abstract;
Antiproliferative action of neomycin is associated with inhibition of cyclin D1 activation in glioma cells: P. Cuevas, et al.; Neurol. Res. 25, 961 (2003), Abstract;
Nerve extracts and substance P activate the phosphatidylinositol signaling pathway and mitogenesis in newt forelimb regenerates: M.J. Smith, et al.; Dev. Biol. 167, 239 (1995), Abstract;
Neomycin inhibition of hormone-stimulated smooth muscle contractions in myometrial tissue: M. Philippe; BBRC 205, 245 (1994), Abstract;
Gadolinium and neomycin block voltage-sensitive Ca2+ channels without interfering with the Na(+)-Ca2+ antiporter in brain nerve endings: L.M. Canzoniero, et al.; Eur. J. Pharmacol. 245, 97 (1993), Abstract;
Inhibition of neural phospholipase D activity by aminoglycoside antibiotics: M. Liscovitch, et al.; Biochem. J. 279, 319 (1991), Abstract;
Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2): E. Gabev, et al.; Biochim. Biophys. Acta 979, 105 (1989), Abstract;
Neomycin is a potent agent for arachidonic acid release in human platelets: S. Nakashima, et al.; BBRC 146, 820 (1987), Abstract;
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation- contraction coupling in muscle: J. Vergara, et al.; PNAS 82, 6352 (1985), Abstract;
Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation: D.H. Carney, et al.; Cell 42, 479 (1985), Abstract;
Effects of neomycin on calcium and polyphosphoinositide metabolism of guinea pig synaptosomes: H.D. Griffin, et al.; J. Neurochem. 34, 750 (1980), Abstract;

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Arachidonic Acid Metabolites
Arachidonic Acid Metabolites
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,