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Concanamycin A

H+ ATPase inhibitor
ALX-380-034-C025 25 µg 246.00 USD
ALX-380-034-C100 100 µg 735.00 USD
ALX-380-034-M001 1 mg 2,580.00 USD
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Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. BML-CM110). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Inhibits Autophagy.

Product Specification

Alternative Name:Folimycin
Source:Isolated from Streptomyces sp.
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:White to off-white solid (sub-milligram quantities will appear as clear film).
Solubility:Soluble in methanol, DMSO or acetonitrile; insoluble in water.
Short Term Storage:+4°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light . Solutions are more stable when stored at -20°C.
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Product Literature References

Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells: V. Teixeira, et al.; Biochim. Biophys. Acta 1861, 21 (2016), Application(s): Cell Culture, Abstract;
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex: S. Ding, et al.; PLoS Pathology 12, e1005929 (2016), Application(s): Cell treatment, Abstract; Full Text
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma: V.K. Emruli, et al.; BMC Cancer 16, 493 (2016), Application(s): Transient knock-down of V-ATPase, Abstract; Full Text
Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1: M.T. Melki, et al.; PLoS Pathog. 6, e1000862 (2010), Abstract; Full Text
Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions: R. Dawaliby, et al.; Mol. Biol. Cell 21, 4173 (2010), Abstract; Full Text
Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis: Y. Xiong, et al.; Plant Physiol. 143, 291 (2007), Abstract;
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells: J. Hong, et al.; J. Pharmacol. Exp. Ther. 319, 672 (2006), Abstract;
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449: S.F. Haydock, et al.; Microbiology 151, 3161 (2005), Abstract; Full Text
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c: M. Huss, et al.; J. Biol. Chem. 277, 40544 (2002), Abstract;
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J. 308 (Pt2), 381 (1995), Abstract;
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995), Abstract;
Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus: M. Muroi, et al.; Cell Struct. Funct. 18, 139 (1993), Abstract;
Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins: M. Muroi, et al.; BBRC 193, 999 (1993), Abstract;
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993), Abstract;
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem. 268, 19092 (1993), Abstract; Full Text
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993), Abstract;
Intravesicular acidification correlates with binding of ADP- ribosylation factor to microsomal membranes: S. Zeuzem, et al.; PNAS 89, 6619 (1992), Abstract;
Structure and function of vacuolar class of ATP-driven proton pumps: M. Forgac; Physiol. Rev. 69, 765 (1989), Abstract;
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988), Abstract;
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984), Abstract;

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