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Colchicine

Inhibitor of tubulin polymerization
 
ALX-380-033-G001 1 g 85.00 USD
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Replaces Prod. #: BML-T118

Depolymerizes microtubules and inhibits tubulin polymerization. Induces apoptosis in a variety of cells.

Product Specification

Formula:C22H25NO6
 
MW:399.4
 
Source:Isolated from Colchicum autumnale.
 
CAS:64-86-8
 
MI:14: 2471
 
RTECS:GH0700000
 
Purity:≥94% (HPLC)
 
Identity:Determined by 1H-NMR and 13C-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (14mg/ml), 100% ethanol (7mg/ml), water (7mg/ml) or dimethylformamide (12mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light and moisture.
 
380-033
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380-033

Product Literature References

Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs: A.R. Choi, et al.; Anticancer Res. 36, 5859 (2016), Application(s): Cell treatment with KBV20C cells, Abstract; Full Text
Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep. 5, 9475 (2015), Application(s): Cell Culture, Abstract; Full Text
Update on colchicine and its mechanism of action: Y. Molad; Curr. Rheumatol. Rep. 4, 252 (2002), Abstract;
Colchicine protects mice from the lethal effect of an agonistic anti- Fas antibody: G. Feng & N. Kaplowitz; J. Clin. Invest. 105, 329 (2000), Abstract;
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells: A.M. Gorman, et al.; Eur. J. Neurosci. 11, 1067 (1999), Abstract;
Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress: Y.L. Hu, et al.; Am. J. Physiol. 277, H1593 (1999), Abstract;
General features of the recognition by tubulin of colchicine and related compounds: Y. Engelborghs; Eur. Biophys. J. 27, 437 (1998), Abstract;
Antimitotic natural products and their interactions with tubulin: E. Hamel et al.; Med. Res. Rev. 16, 207 (1996), Abstract;
Colchicine induces apoptosis in cerebellar granule cells: E. Bonfoco, et al.; Exp. Cell. Res. 218, 189 (1995), Abstract;
Inhibition of drug-induced apoptosis by survival factors in PC12 cells: L. Lindenboim, et al.; J. Neurochem. 64, 1054 (1995), Abstract;
Disruption of microtubules inhibits the stimulation of tissue plasminogen activator expression and promotes plasminogen activator inhibitor type 1 expression in human endothelial cells: L. Santell, et al.; Exp. Cell. Res. 201, 358 (1992), Abstract;
The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells: M.F. Lueng & A.C. Sartorelli; Leuk. Res. 16, 929 (1992), Abstract;
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine: E.D. Salmon, et al.; J. Cell. Biol. 99, 1066 (1984), Abstract;
Proposed mechanism for colchicine poisoning of microtubules reassembled in vitro from Strongylocentrotus purpuratus sperm tail outer doublet tubulin: K.W. Farrell & L. Wilson; Biochemistry 19, 3048 (1980), Abstract;
Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change: D.L. Garland; Biochemistry 17, 4266 (1978), Abstract;
Fluorometric assay of tubulin-colchicine complex: T. Arai & T. Okuyama; Anal. Biochem. 69, 443 (1975), Abstract;
A new colchicine binding assay for tubulin: P. Sherline, et al.; Anal. Biochem. 62, 400 (1974), Abstract;

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