FK506

Immunosuppressant



ALX-380-008-M001	1 mg	29.00 USD

ALX-380-008-M005	5 mg	62.00 USD

ALX-380-008-M025	25 mg	186.00 USD

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK506 binding protein and to inhibit the Ca²⁺-dependent phosphatase and protein phosphatase 2B (PP2B; calcineurin). Activates NF-κB through phosphorylation and degradation of IκBα.

Product Specification

Alternative Name:	Tacrolimus

Formula:	C₄₄H₆₉NO₁₂ . H₂O

MW:	804.0 . 18.0

Purity:	≥98%

Appearance:	White to off-white crystalline powder.

CAS:	104987-11-3

MI:	14: 9025

RTECS:	KD4200000

Source/Host:	Isolated from Streptomyces tsukubaensi.

Solubility:	Soluble in DMSO, 100% ethanol, methanol, ethyl acetate or acetone; insoluble in water.

Long Term Storage:	-20°C

Hazard:	TOXIC.

Handling:	Protect from light.

Please mouse over

Product Literature References

A review of the action of tacrolimus (FK506) on experimental models of rheumatoid arthritis: S. Miyata, et al.; Inflamm. Res. 54, 1 (2005), Review, Abstract;

FK506 and its analogs - therapeutic potential for neurological disorders: A. Klettner and T. Herdegen; Curr. Drug Targets CNS Neurol. Disord. 2, 153 (2003), Review, Abstract;

FK506, an immunosuppressant targeting calcineurin function: F.J. Dumont; Curr. Med. Chem. 7, 731 (2000), Abstract;

Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites: Y. Zhang, et al.; J. Biol. Chem. 274, 34657 (1999), Abstract; Full Text

Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology: B.E. Bierer, et al.; Curr. Opin. Immunol. 5, 763 (1993), Abstract;

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression: J. Kunz and M.N. Hall; TIBS 18, 334 (1993), Abstract;

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics: T. Kino, et al.; J. Antibiot. (Tokyo) 40, 1249 (1987), Abstract;