Manumycin B



ALX-350-427-M001	1 mg	234.00 USD

ALX-350-427-M005	5 mg	735.00 USD

Inhibitor of Ras farnesyltransferase.
AChE inhibitor (more selective over BuChE).
Active against Gram-positive bacteria.
Shows apoptosis inhibiting activity.

Product Specification

Formula:	C₂₈H₃₄N₂O₇

MW:	510.6

Source:	Isolated from Streptomyces parvulus.

CAS:	139023-58-8

Purity:	≥98% (HPLC)

Identity:	Identity determined by ¹H-NMR and UV.

Appearance:	Yellow to brown powder.

Solubility:	Soluble in methanol or DMSO.

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Handling:	Protect from light.

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Product Literature References

Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol. 298, F1393 (2010), Abstract; Full Text

An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays: F. Zanella, et al.; Assay Drug Dev. Technol. 5, 333 (2007), Abstract;

Isolation and characterization of N98-1272 A, B and C, selective acetylcholinesterase inhibitors from metabolites of an actinomycete strain: Z.H. Zheng, et al.; J. Enzyme Inhib. Med. Chem. 22, 43 (2007), Abstract;

Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006), Abstract;

Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005), Abstract;

Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001), Abstract;

Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000), Abstract;

Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes: Y. Zou et al.; J. Biol. Chem. 271, 33592 (1996), Abstract;

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994), Abstract;

Identification of Ras farnesyltransferase inhibitors by microbial screening: M. Hara et al.; PNAS 90, 2281 (1993), Abstract;

Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review), Abstract;