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Manumycin B

 
ALX-350-427-M001 1 mg 234.00 USD
 
ALX-350-427-M005 5 mg 735.00 USD
 
Inhibitor of Ras farnesyltransferase.
AChE inhibitor (more selective over BuChE).
Active against Gram-positive bacteria.
Shows apoptosis inhibiting activity.

Product Specification

Formula:C28H34N2O7
 
MW:510.6
 
Source:Isolated from Streptomyces parvulus.
 
CAS:139023-58-8
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and UV.
 
Appearance:Yellow to brown powder.
 
Solubility:Soluble in DMSO, methanol or chloroform.
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:After reconstitution protect from light at -20°C.
 
350-427
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350-427

Product Literature References

Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol. 298, F1393 (2010), Abstract; Full Text
An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays: F. Zanella, et al.; Assay Drug Dev. Technol. 5, 333 (2007), Abstract;
Isolation and characterization of N98-1272 A, B and C, selective acetylcholinesterase inhibitors from metabolites of an actinomycete strain: Z.H. Zheng, et al.; J. Enzyme Inhib. Med. Chem. 22, 43 (2007), Abstract;
Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006), Abstract;
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005), Abstract;
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001), Abstract;
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000), Abstract;
Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes: Y. Zou et al.; J. Biol. Chem. 271, 33592 (1996), Abstract;
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994), Abstract;
Identification of Ras farnesyltransferase inhibitors by microbial screening: M. Hara et al.; PNAS 90, 2281 (1993), Abstract;
Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review), Abstract;

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