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Andrastin A

Farnesyltransferase inhibitor
ALX-350-418-M001 1 mg Inquire for pricing
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Farnesyltransferase inhibitor with antitumor properties. Inhibits the efflux of anticancer drugs from multidrug-resistant cancer cells. Secondary fungal metabolite from Penicillium and Aspergillus.

Product Specification

Alternative Name:Methyl-3-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylate
Source:Isolated from Aspergillus fumigatus.
Purity:≥95% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO, methanol, chloroform or ethyl acetate; insoluble in hexane or water.
Long Term Storage:-20°C
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Product Literature References

Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Mycotoxins and other secondary metabolites produced in vitro by Penicillium paneum Frisvad and Penicillium roqueforti Thom isolated from baled grass silage in Ireland: M. O'Brien, et al.; J. Agric. Food Chem. 54, 9268 (2006), Abstract;
Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications: D.P. Overy, et al.; Mycol. Res. 109, 1243 (2005), Abstract;
Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese: K.F. Nielsen, et al.; J. Agric. Food Chem. 53, 2908 (2005), Abstract;
Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking: A. Pedretti, et al.; J. Med. Chem. 45, 1460 (2002), Abstract;
Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells: M.C. Rho, et al.; J. Antibiot. (Tokyo) 51, 68 (1998), Abstract; Full Text
Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis: R. Uchida, et al.; J. Antibiot. (Tokyo) 49, 418 (1996), Abstract;

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