Andrastin A

Farnesyltransferase inhibitor



ALX-350-418-MC25	0.25 mg	77.00 USD

ALX-350-418-M001	1 mg	232.00 USD

Farnesyltransferase inhibitor with antitumor properties. Inhibits the efflux of anticancer drugs from multidrug-resistant cancer cells. Secondary fungal metabolite from Penicillium and Aspergillus.

Product Specification

Formula:	C₂₈H₃₈O₇

MW:	486.6

Purity:	≥95% (HPLC)

Appearance:	White to off-white powder.

CAS:	174232-42-9

Source/Host:	Isolated from Aspergillus fumigatus.

Solubility:	Soluble in DMSO, methanol, chloroform or ethyl acetate; insoluble in hexane or water.

Long Term Storage:	-20°C

Hazard:	HARMFUL.

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Product Literature References

Mycotoxins and other secondary metabolites produced in vitro by Penicillium paneum Frisvad and Penicillium roqueforti Thom isolated from baled grass silage in Ireland: M. O'Brien, et al.; J. Agric. Food Chem. 54, 9268 (2006), Abstract;

Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications: D.P. Overy, et al.; Mycol. Res. 109, 1243 (2005), Abstract;

Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese: K.F. Nielsen, et al.; J. Agric. Food Chem. 53, 2908 (2005), Abstract;

Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking: A. Pedretti, et al.; J. Med. Chem. 45, 1460 (2002), Abstract;

Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells: M.C. Rho, et al.; J. Antibiot. (Tokyo) 51, 68 (1998), Abstract; Full Text

Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis: R. Uchida, et al.; J. Antibiot. (Tokyo) 49, 418 (1996), Abstract;