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Phomopsin A

 
ALX-350-417-M001 1 mg 526.00 USD
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A potent mycotoxin and anti-mitotic compound. Causes lupinosis in livestock fed infected lupins. Binds selectively to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Binds to tubulin at a site overlapping that of vinblastine (Prod. No. ALX-350-257) and maytansine. Protects tubulin from decay.

Product Specification

Formula:C36H45ClN6O12
 
MW:789.2
 
Source:Isolated from Phomopsis leptostromiformis MST-FP2068.
 
CAS:64925-80-0
 
RTECS:SY2593000
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethylformamide or DMSO; slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-417
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350-417

Product Literature References

Interaction of phomopsin A with normal and subtilisin-treated bovine brain tubulin: A.R. Chaudhuri & R.F. Luduena; J. Protein Chem. 16, 99 (1997), Abstract;
The interaction of phomopsin A with bovine brain tubulin: R.F. Luduena, et al.; Arch. Biochem. Biophys. 272, 32 (1989), Abstract;
Interaction of phomopsin A and related compounds with purified sheep brain tubulin: E. Lacey, et al.; Biochem. Pharmacol. 36, 2133 (1987), Abstract;

General Literature References

Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B: E. Hamel; Pharmacol. Ther. 55, 31 (1992), Abstract;

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