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Neoxaline

Antimitotic and antiproliferative agent
 
ALX-350-409-M001 1 mg 106.00 USD
 
ALX-350-409-M005 5 mg 424.00 USD
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Alkaloid. Antimitotic / antiproliferative agent. Belongs to a class of biologically active indole alkaloids characterized by a unique spiroaminal framework.The antiproliferative activity against Jurkat cells was evaluated by MTT assay. Has been shown to inhibit cell proliferation in a dose dependent manner with an IC50 value of 43.7µM. After 15-20h of neoxaline treatment (70µM), an accumulation of cells at the G2/M phase was observed, showing that the antiproliferative activity of neoxaline is due to an arrest of the cell cycle at the G2/M phase. Has a weak inhibitory activity on blood platelet aggregation induced by stimulation of the central nervous system.

Product Specification

Alternative Name:7a-(1,1-Dimethyl-2-propenyl)-6,7,7a,12-tetrahydro-6-hydroxy-3-(1H-imidazol-4-yl-methylene)-12-methoxy-1H,5H-imidazo[1’,2’:1,2]pyrido[2,3-b]indole-25(3H)dione
 
Formula:C23H25N5O4
 
MW:435.48
 
Source:Isolated from Aspergillus japonicus Fg-551.
 
CAS:71812-10-7
 
Purity:≥97% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in acetone, chloroform, ethyl acetate or methanol; insoluble in water or hexane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:Manufactured with courtesy strain from The Kitasato Institute. 
 
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Product Literature References

Efficient total synthesis of novel bioactive microbial metabolites.: T. Sunazuka, et al.; Acc. Chem. Res. 41, 302 (2008), Abstract;
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization.: Y. Koizumi, et al.; Biochim. Biophys. Acta 1693, 47 (2004), Abstract;
Oxaline and Neoxaline.: Y Konda, et al.; Chem. Pharm. Bull. 28, 2987 (1980), Abstract; Full Text
Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties.: A. Hirano, et al.; J. Antibiot. 32, 781 (1979), Abstract;

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