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Geodin

PAI-1 inhibitor
 
ALX-350-408-M005 5 mg 246.00 USD
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Inhibitor of plasminogen activator inhibitor (PAI-1).

Product Specification

Alternative Name:Erdin (+)-form methyl ester, (R)-5,7-Dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester
 
Formula:C17H12Cl2O7
 
MW:399.18
 
Source:Isolated from Penicillum sp. FKI-5002.
 
CAS:427-63-4
 
MI:12: 3682 (monograph retired)
 
Purity:≥95% (HPLC)
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in acetone, chloroform, DMSO, ethyl acetate or methanol; insoluble in water or hexane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Scientific Background:Geodin is the methyl ester form of the (+)-form of erdin. It contains two chlorine and was first isolated from the mold fungus Aspergillus terreus. Chemically, geodin is a seco-anthraquinone derivated from an octaketide anthraquinone.
 
Technical Info/Product Notes:Manufactured with courtesy strain from The Kitasato Institute.
 
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Product Literature References

Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B.: C. Shinohara, et al.; J. Antibiot. 53, 262 (2000), Abstract;
Studies in the biochemistry of micro-organisms: The molecular constitution of geodin and erdin, two chlorine-containing metabolic products of Aspergillus terreus Thom. Part I. The constitutional relationship of geodin and erdin.: P.W. Clutterbuck, et al.; Biochem. J. 31, 1089 (1937), Abstract;
Studies in the biochemistry of micro-organisms: The metabolic products of Aspergillus terreus Thom. Part II. Two new chlorine-containing mould metabolic products, geodin and erdin.: H. Raistrick & G. Smith; Biochem. J. 30, 1315 (1936), Abstract;

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