Benzoic acid. Blocks PAF-mediated neuronal apoptosis. Shows free radical scavenging activity.
Product Specification
| Alternative Name: | 2,4-Dihydroxy-6-methylbenzoic acid, Orsellic acid |
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| Formula: | C8H8O4 |
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| MW: | 168.1 |
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| Source: | Isolated from fungus Chaetomium sp. |
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| CAS: | 480-64-8 |
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| MI: | 14: 6881 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Identity determined by 1H-NMR and ESI-MS. |
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| Appearance: | Solid. |
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| Solubility: | Soluble in water, DMSO or 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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Product Literature References
Radical-scavenging activity of orsellinates: T.I. Lopes, et al.; Chem. Pharm. Bull. (Tokyo)
56, 1551 (2008),
Abstract;
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Plant phenolics regulate neoplastic cell growth and survival: a quantitative structure-activity and biochemical analysis: C.S. Harris, et al.; Can. J. Physiol. Pharmacol.
85, 1124 (2007),
Abstract;
Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid: S.D. Ryan, et al.; J. Neurochem.
103, 88 (2007),
Abstract;
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Cytotoxic activity of orsellinates: A.T. Gomes, et al.; Z. Naturforsch. [C]
61, 653 (2006),
Abstract;
Isolation and identification of orsellinic acid and penicillic acid produced by Penicillium fennelliae Stolk: G.W. van Eijk; Antonie Van Leeuwenhoek
35, 497 (1969),
Abstract;
Studies on the biosynthesis of phenols in fungi. Conversion of [14C]orsellinic acid and [14C]orcinol into fumigatol by Aspergillus fumigatus I.M.I. 89353: N.M. Packter; Biochem. J.
98, 353 (1966),
Abstract;
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A Synthesis of Orsellinic Acid: R.A. Kloss & D.A. Clayton; J. Org. Chem.
30, 3566 (1965),
Abstract;
Studies in the biochemistry of micro-organisms. 110. Production and biosynthesis of orsellinic acid by Penicillium madriti G. Smith: J.H. Birkinshaw & A. Gowlland; Biochem. J.
84, 342 (1962),
Abstract;
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