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Oridonin

Antitumor agent
 
ALX-350-390-M050 50 mg 168.00 USD
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Diterpene with potent anti-tumor activity. Induces apoptosis and autophagy.

Product Specification

Alternative Name:Isodonol
 
Formula:C20H28O6
 
MW:364.4
 
Source:Isolated from Rabdosia rubescens
 
CAS:28957-04-2
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (20mg/ml) or PEG 400; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
350-390
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350-390

Product Literature References

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells: Y. Cheng et al.; Autophagy 5, 430 (2009), Abstract;
Apoptotic effect of oridonin on NB4 cells and its mechanism: J. Liu, et al.; Leuk. Lymphoma 46, 593 (2005), Abstract;
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways: T. Ikezoe, et al.; Mol. Cancer Ther. 4, 578 (2005), Abstract;
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells: T. Ikezoe, et al.; Int. J. Oncol. 23, 1187 (2003), Abstract;

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