2-Bromoaldisine

Inhibitor of the Raf/MEK-1/MAPK cascade



ALX-350-388-MC05	0.5 mg	98.00 USD

Inhibitor of the Raf/MEK-1/MAPK cascade (IC₅₀= 539nM).

Product Specification

Identity:	Identity determined by ¹H-NMR and ESI-MS.

Formula:	C₈H₇BrN₂O₂

MW:	243.1

Purity:	≥96% (HPLC)

Appearance:	White to off-white powder.

CAS:	96562-96-8

Source/Host:	Isolated from sponge Pseudaxynissa sp.

Solubility:	Soluble in DMSO or 100% ethanol.

Long Term Storage:	-20°C

Handling:	Protect from light.

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Product Literature References

Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin: F. Tutino, et al.; Tetrahedron 65, 2372 (2009), Abstract;

Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa: A. Aiello, et al.; Bioorg. Med. Chem. 14, 17 (2006), Abstract;

Synthesis and target identification of hymenialdisine analogs: Y. Wan, et al.; Chem. Biol. 11, 247 (2004), Abstract;

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002), Abstract;

Total syntheses of hymenialdisine and debromohymenialdisine: Stereospecific construction of the 2-amino-4-oxo-2-imidazolin-5(Z)-disubstituted y ylidene ring system: H. Annoura & T. Tatsuoka; THL 36, 413 (1995), Abstract;

Marine natural products: pyrrololactams from several sponges: F.J. Schmitz, et al.; J. Nat. Prod. 48, 47 (1985), Abstract;

Anti-Cancer Metabolites from Marine Sponges: D. Tasdemir; Biodiversity: Biomolecular Aspects of Biodiversity and Innovative Utilization 2002, 187 (0), Abstract;