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2-Bromoaldisine

Inhibitor of the Raf/MEK-1/MAPK cascade
 
ALX-350-388-MC05 0.5 mg 103.00 USD
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Inhibitor of the Raf/MEK-1/MAPK cascade (IC50= 539nM).

Product Specification

Formula:C8H7BrN2O2
 
MW:243.1
 
Source:Isolated from sponge Pseudaxynissa sp.
 
CAS:96562-96-8
 
Purity:≥96% (HPLC)
 
Identity:Identity determined by 1H-NMR and ESI-MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
350-388
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350-388

Product Literature References

Stereoselective synthesis of (Z)-axino- and (Z)-debromoaxinohydantoin: F. Tutino, et al.; Tetrahedron 65, 2372 (2009),
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa: A. Aiello, et al.; Bioorg. Med. Chem. 14, 17 (2006), Abstract;
Synthesis and target identification of hymenialdisine analogs: Y. Wan, et al.; Chem. Biol. 11, 247 (2004), Abstract;
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002), Abstract;
Anti-Cancer Metabolites from Marine Sponges: D. Tasdemir; Biodiversity: Biomolecular Aspects of Biodiversity and Innovative Utilization 187 (2002), (Book), Abstract;
Total syntheses of hymenialdisine and debromohymenialdisine: Stereospecific construction of the 2-amino-4-oxo-2-imidazolin-5(Z)-disubstituted y ylidene ring system: H. Annoura & T. Tatsuoka; THL 36, 413 (1995),
Marine natural products: pyrrololactams from several sponges: F.J. Schmitz, et al.; J. Nat. Prod. 48, 47 (1985), Abstract;

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