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Genipin

UCP2 inhibitor
 
ALX-350-383-M025 25 mg 72.00 USD
 
ALX-350-383-M100 100 mg 243.00 USD
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Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic.

Product Specification

Alternative Name:(+)-Genipin, Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
 
Formula:C11H14O5
 
MW:226.2
 
Source:Isolated from Gardenia jasminoides Ellis.
 
CAS:6902-77-8
 
RTECS:GY5828000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (5mg/ml), methanol or ethyl acetate; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-383
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350-383

Product Literature References

In situ formation of silk-gelatin hybrid hydrogels for affinity-based growth factor sequestration and release: J.C. Bragg, et al.; RSC Advances 6, 114353 (2016),
Tissue engineering of ureteral grafts: Preparation of biocompatible crosslinked ureteral scaffolds of porcine origin: H. Koch, et al.; Front. Bioeng. Biotechnol. 3, 89 (2015), Application(s): Cell Culture, Abstract; Full Text
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity: L.E. Parton, et al.; Nature 449, 228 (2007), Abstract;
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets: C.Y Zhang, et al.; Cell Metab. 3, 417 (2006), Abstract;
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway: B.C. Kim, et al.; Biochem. Pharmacol. 70, 1398 (2005), Abstract;

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