Cytisine



ALX-350-373-M005	5 mg	35.00 USD

ALX-350-373-M025	25 mg	120.00 USD

Pyridine-like alkaloid. Nicotine agonist. Potent ligand for many nAChR subtypes. Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities.

Product Specification

Identity:	Identity determined by ¹H-NMR.

Formula:	C₁₁H₁₄N₂O

MW:	190.2

Purity:	≥95% (HPLC)

Appearance:	Light to dark yellow powder.

CAS:	485-35-8

MI:	14:2789

RTECS:	HA4025000

Source/Host:	Isolated from seeds of Laburnum anagyroides

Solubility:	Soluble in benzene, acetone, ethyl acetate or 100% ethanol; sparingly soluble in water or methanol.

Shipping:	SHIPPED ON BLUE ICE

Long Term Storage:	-20°C

Hazard:	TOXIC.

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Product Literature References

Some studies on cytisine and its methylated derivatives: R.B. Barlow & L.J. McLeod; Br. J. Pharmacol. 35, 161 (1969), Abstract; Full Text

Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay: T.S. Rao, et al.; Neuropharmacology 35, 393 (1996), Abstract;

Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release: P.B. Clarke & M. Reuben; Br. J. Pharmacol. 117, 595 (1996), Abstract; Full Text

Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998), Abstract;

Inherited, selective hypoanalgesic response to cytisine in the tail-flick test in CF-1 mice: T.W. Seale, et al.; Neuroreport 9, 201 (1998), Abstract;

Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurones show different agonist profiles: D. Kristufek, et al.; J. Physiol. 516, 739 (1999), Abstract; Full Text

Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003), Abstract;

Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities: C.C. Boido, et al.; Farmaco 58, 265 (2003), Abstract;

Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes: E. Carbonnelle, et al.; Eur. J. Pharmacol. 471, 85 (2003), Abstract;

Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003), Abstract;

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007), Abstract; Full Text

Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat: J.W. Smith, et al.; Psychopharmacology (Berl) 190, 157 (2007), Abstract;