Pectenotoxin-2

Cytotoxic agent



ALX-350-369-C005	5 µg	371.00 USD

Potent disruptor of actin cytoskeleton in living cells. Forms 1:1 complexes with monomeric actin and caps actin filaments. Selective cytotoxic agent against several human cancer cell lines. Hepatotoxic.

Product Specification

Alternative Name:	4,3-Dioxypectenotoxin, PTX-2

Concentration:	10µg/ml

Formula:	C₄₇H₇₀O₁₄

MW:	859.1

Purity:	≥95% (HPLC)

Formulation:	Liquid. In methanol.

CAS:	97564-91-5

Source/Host:	Isolated from Dinophysis spp.

Long Term Storage:	-20°C

Hazard:	VERY TOXIC.

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Product Literature References

Impact of the pectenotoxin C-43 oxidation degree on its cytotoxic effect on rat hepatocytes: B. Espina, et al.; Chem. Res. Toxicol. 23, 504 (2010), Abstract;

Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C: D.O. Moon, et al.; Oncol. Rep. 24, 271 (2010), Abstract;

Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin: B. Espina & J.A. Rubiolo; Febs J 275, 6082 (2008), Abstract;

A structural basis for regulation of actin polymerization by pectenotoxins: J.S. Allingham, et al.; J. Mol. Biol. 371, 959 (2007), Abstract;

Oocyte-based screening of cytokinesis inhibitors and identification of pectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors: H.D. Chae, et al.; Oncogene 24, 4813 (2005), Abstract;

New anti-actin drugs in the study of the organization and function of the actin cytoskeleton: I. Spector, et al.; Microsc. Res. Tech. 47, 18 (1999), Abstract;

Cytotoxic compounds from a two-sponge association: J.H. Jung, et al.; J. Nat. Prod. 58, 1722 (1995), Abstract;