Cinnamtannin B-1

[Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin]



ALX-350-365-M005	5 mg	230.00 USD

A-type proanthocyanidin contained in several plant species such as Laurus nobilis L.Vaccinium vitis-idaeaParameria laevigataCinnamomum zeylanicumLindera umbellata Metaxya rostrataPotent antioxidant, TEAC method (nM Trolox) = 0.95Protective agent against oxidative stress and apoptosis in human platelets.

Product Specification

Formula:	C₄₅H₃₆O₁₈

MW:	864.7

Purity:	≥90% (¹H-NMR)

Appearance:	Brown solid.

CAS:	88082-60-4

Source/Host:	Isolated from Laurus nobilis L.

Solubility:	Soluble in 100% ethanol, methanol or in a mixture of DMSO and water.

Shipping:	AMBIENT

Long Term Storage:	-20°C

Handling:	Keep under inert gas. Protect from light.

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Product Literature References

Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice: N. Ezaki, et al.; Planta Med. 51, 34 (1985), Abstract;

Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod. 55, 1033 (1992), Abstract;

Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol. 51, 1075 (1999), Abstract;

Studies on the constituents of bark of Parameria laevigata Moldenke: K. Kamiya, et al.; Chem. Pharm. Bull. 49, 551 (2001), Abstract; Full Text

Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia 59, 97 (2004), Abstract;

Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006), Abstract;

Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem. 50, 3937 (2007), Abstract;

Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis 12, 489 (2007), Abstract;

Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007), Abstract;

Chemical and Pharmacological Investigations of Metaxya rostrata: J. Wirtbauer, et al.; Z. Naturforsch. 63, 465 (2008), Abstract;

Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor: J. J. López, et al.; Life Sciences 82, 977 (2008), Abstract;

Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells: M. Fernandez-Sanchez, et al.; BMC Cell Biol. 10, 77 (2009), Abstract;

Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion: S. Dall'Acqua, et al.; J. Med. Food 12, 869 (2009), Abstract;