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Magnolol

Antitumor and anti-angiogenic agent
 
ALX-350-352-M005 5 mg 56.00 USD
 
ALX-350-352-M025 25 mg 265.00 USD
Do you need bulk/larger quantities?
 
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).

Product Specification

Alternative Name:5,5’-Diallyl-2,2’-biphenyldiol
 
Formula:C18H18O2
 
MW:266.3
 
Source:Isolated from Magnolia officinalis.
 
CAS:528-43-8
 
MI:14: 5697
 
RTECS:DV5105500
 
Purity:≥98% (HPLC)
 
Appearance:White to light yellow powder.
 
Solubility:Soluble in DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
350-352
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350-352

Product Literature References

Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007), Abstract; Full Text
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006), Abstract; Full Text
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003), Abstract;
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000), Abstract;
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998), Abstract;
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983), Abstract;

Related Products

Honokiol 

iNOS inhibitor
35354-74-6, Isolated from Magnolia officinalis., ≥98% (HPLC) | Print as PDF
 
ALX-350-350-M005 5 mg 43.00 USD
 
ALX-350-350-M025 25 mg 198.00 USD
Do you need bulk/larger quantities?
 

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