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Galiellalactone

STAT3 inhibitor
 
ALX-350-336-MC05 0.5 mg 434.00 USD
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Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.

Product Specification

Formula:C11H14O3
 
MW:194.2
 
Source:Isolated from an unidentified fungus, MST-FP1889.
 
CAS:133613-71-5
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:White to light tan solid.
 
Solubility:Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-336
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350-336

Product Literature References

Immune Regulation of Interleukin-27 in Malignant Pleural Effusion: S. Li, et al.; Chin. Med. J. (Engl) 128, 1932 (2015), Abstract; Full Text
Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3: R. Hellsten, et al.; Prostate 68, 269 (2008), Abstract;
Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities: B. Kopcke, et al.; J. Antibiot. (Tokyo) 55, 36 (2002), Abstract;
Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota): B. Kopcke, et al.; Phytochemistry 60, 709 (2002), Abstract;
Synthesis of (-)-galiellalactone: M. Johansson and O. Sterner; J. Antibiot. (Tokyo) 55, 663 (2002), Abstract;
Inhibition of interleukin-6 signaling by galiellalactone: M. Weidler, et al.; FEBS Lett. 484, 1 (2000), Abstract;
Screening of basidiomycetes and ascomycetes for plant regulating substances: R. Hautzel and H. Anke; Z. Naturforsch. 45c, 1094 (1990),

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