3-O-Acetyl-β-boswellic acid

Inhibitor of lipoxygenase and topoisomerase



ALX-350-308-M001	1 mg	30.00 USD

ALX-350-308-M005	5 mg	123.00 USD

Shows antitumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-100 times more potent than natural boswellic acid.

Product Specification

Alternative Name:	AβBA

Formula:	C₃₂H₅₀O₄

MW:	498.8

Purity:	≥98% (HPLC)

Appearance:	White to off-white solid.

CAS:	5968-70-7

Source/Host:	Isolated from Boswellia sp.

Solubility:	Soluble in acetone, dimethyl formamide, DMSO, dichloromethane, 100% ethanol or methanol; sparingly soluble in water.

Long Term Storage:	-20°C

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Product Literature References

Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review, Abstract;

Effects of Boswellia serrata in mouse models of chemically induced colitis: P.R. Kiela, et al.; Am. J. Physiol. Gastrointest. Liver. Physiol. 288, G798 (2005), Abstract;

Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid: D. Poeckel, et al.; Br. J. Pharmacol. 146, 514 (2005), Abstract;

Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005), Abstract; Full Text

Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers: V. Sterk, et al.; Planta Med. 70, 1155 (2004), Abstract;