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S14-95

STAT1α inhibitor
 
ALX-350-299-MC05 0.5 mg 254.00 USD
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Potent inhibitor of cytokine-induced activation of STAT1α leading to the inhibition of inducible expression of proinflammatory enzymes (COX-2, iNOS (NOS II)) and cytokines (TNF-α).

Product Specification

Formula:C28H34O5
 
MW:450.6
 
Source:Isolated from Penicillium sp.
 
Purity:≥95% (HPLC)
 
Identity:Determined by MS.
 
Appearance:Yellow powder.
 
Solubility:Soluble in methanol.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
350-299
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350-299

Product Literature References

Immune Regulation of Interleukin-27 in Malignant Pleural Effusion: S. Li, et al.; Chin. Med. J. (Engl) 128, 1932 (2015), Abstract; Full Text
S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species: G. Erkel, et al.; J. Antibiot. 56, 337 (2003), Abstract; Full Text
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003), Abstract; Full Text

General Literature References

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases: T. Itoh, et al.; Nat. Chem. 2, 858 (2010), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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