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CDK1 inhibitor
ALX-350-293-M001 1 mg 38.00 USD
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(S)-Enantiomer of the CDK inhibitor roscovitine (Prod. No. BML-CC205). Potent inhibitor of CDK1/cyclin B kinase (IC50=950nM).

Product Specification

Alternative Name:6-Benzylamino-2-(S)-[(1-Ethyl)-2-hydroxyethylamino]-9-isopropylpurine
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol.
Long Term Storage:-20°C
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Product Literature References

Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation: V. Yarotskyy, et al.; J. Biol. Chem. 285, 43 (2010), Abstract;
In vitro maturation and fertilization of porcine oocytes after a 48 h culture in roscovitine, an inhibitor of p34cdc2/cyclin B kinase: R. Romar & H. Funahashi; Anim. Reprod. Sci. 92, 321 (2006), Abstract;
Maintenance of meiotic arrest in bovine oocytes using the S-enantiomer of roscovitine: effects on maturation, fertilization and subsequent embryo development in vitro: P. Coy, et al.; Reproduction 129, 19 (2005), Abstract;
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998), Abstract;
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997), Abstract;
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine: W.F. De Azevedo, et al.; Eur. J. Biochem. 243, 518 (1997), Abstract;

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