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Isoxanthohumol

Phytoestrogen



ALX-350-279-M001	1 mg	93.00 USD
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Racemic mixture of (+/-)-Isoxanthohumol.
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.

Product Details

Alternative Name:	(±)-Isoxanthohumol

Formula:	C₂₁H₂₂O₅

MW:	354.4

Source:	Synthetic.

CAS:	521-48-2

Purity:	≥98% (¹H-NMR)

Identity:	Determined by ¹H-NMR, ¹³C-NMR and LC-MS.

Appearance:	Off-white to yellow powder.

Solubility:	Soluble in DMSO (50mg/ml) or methanol (50mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Inhibition of TGF-beta signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol: A. Serwe, et al.; Invest. New Drugs 30, 898 (2012), Abstract;

Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions: D. Stracke, et al.; Mol. Nutr. Food Res. 55, 485 (2010), Abstract;

Endocrine Disrupting Compounds (EDCs): Disrupting Human Endocrine Physiology and the Intricate Reproductive Balance: S.A. Sidiropoulos; UTMJ 85, 76 (2008), Abstract;

The Impact of a Xanthohumol-Enriched Hop Product on the Behavior of Xanthohumol and Isoxanthohumol in Pale and Dark Beers: A Pilot Scale Approach: P.J. Magalhaes, et al.; J. Inst. Brew. 114, 246 (2008), Full Text

Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007), Abstract;

Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos. 34, 1152 (2006), Abstract;

The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr. 136, 1862 (2006), Abstract;

Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom. 40, 289 (2005), Abstract;

Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC 325, 287 (2004), Abstract;

Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review), Abstract;