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Pseudohypericin

Inhibitor of PKC and dopamine β-hydroxylase
 
ALX-350-276-M001 1 mg 124.00 USD
 
ALX-350-276-M005 5 mg 482.00 USD
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Inhibitor of protein kinase C (PKC) (IC50=15µg/ml). Antiviral and antiretroviral activity. Potent inhibitor of dopamine-β-hydroxylase (IC50=3µg/ml).

Product Specification

Formula:C30H16O9
 
MW:520.5
 
Source:Isolated from Hypericum perforatum.
 
CAS:55954-61-5
 
Purity:≥98% (HPLC, TLC)
 
Appearance:Black to black-red powder.
 
Solubility:Soluble in methanol, 100% ethanol, DMSO, acetone and other organic solvents.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
350-276
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350-276

Product Literature References

Antagonist effect of pseudohypericin at CRF1 receptors: U. Simmen, et al.; Eur. J. Pharmacol. 458, 251 (2003), Abstract;
Phototoxic and apoptosis-inducing capacity of pseudohypericin: C.M. Schempp, et al.; Planta Med. 68, 171 (2002), Abstract;
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids: A. Denke, et al.; Arzneimittelforschung 50, 415 (2000), Abstract;
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989), Abstract;
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin: G. Lavie, et al.; PNAS 86, 5963 (1989), Abstract;
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS 85, 5230 (1988), Abstract;
Zur Isolierung und Konstitution des Pseudohypericins : H. Brockmann, et al.; Tetrahedron Lett. 15, 1991 (1974),

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