α-Amanitin

RNA polymerase II inhibitor



ALX-350-270-M001	1 mg	186.00 USD

Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.

Product Specification

Formula:	C₃₉H₅₄N₁₀O₁₄S

MW:	919.0

Purity:	≥90%

Appearance:	White to light yellow powder.

CAS:	23109-05-9

MI:	14: 373

RTECS:	BD6195000

Source/Host:	Isolated from Amanita phalloides mushrooms.

Solubility:	Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.

Long Term Storage:	-20°C

Use/Stability:	Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.

Hazard:	VERY TOXIC.

Handling:	Protect from light.

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Product Literature References

Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004), Abstract;

Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review), Abstract;

Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970), Abstract;

Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967), Abstract;