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α-Amanitin

RNA polymerase II inhibitor
 
ALX-350-270-M001 1 mg 209.00 USD
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Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.

Product Specification

Formula:C39H54N10O14S
 
MW:919.0
 
Source:Isolated from Amanita phalloides mushrooms.
 
CAS:23109-05-9
 
MI:14: 373
 
RTECS:BD6195000
 
Purity:≥90%
 
Appearance:White to light yellow powder.
 
Solubility:Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
 
Handling:Protect from light.
 
ALX-350-270 structure
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ALX-350-270 structure

Product Literature References

Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004), Abstract;
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review), Abstract;
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970), Abstract;
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967), Abstract;

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