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Trichodion

Inhibitor NF-κB, AP-1 and STAT1alpha mediated gene expression
 
ALX-350-261-C500 500 µg 246.00 USD
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Cytotoxic. Inhibits NF-κB (IC50=42-84µM), AP-1 (IC50=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.

Product Specification

Formula:C12H14O5
 
MW:238.2
 
Source:Isolated from Trichosporiella sp.
 
CAS:294660-43-8
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-350-261
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ALX-350-261

Product Literature References

Trichodion, a new bioactive pyrone from a Trichosporiella species: G. Erkel, et al.; J. Antibiot. (Tokyo) 53, 1401 (2000), Abstract;
Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species: G. Erkel; FEBS Lett. 477, 219 (2000), Abstract;

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