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Vinblastine . sulfate

Cell cycle blocker
 
ALX-350-257-M005 5 mg 64.00 USD
 
ALX-350-257-M025 25 mg 244.00 USD
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Replaces Prod. #: BML-T116

Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule asembly and causes aberant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent.

Product Specification

Alternative Name:Vincaleukoblastine . sulfate
 
Formula:C46H58N4O9 . H2SO4
 
MW:909.1
 
Source:Semisynthetic from catharanthine or vindoline.
 
CAS:143-67-9
 
MI:14: 9982
 
Purity:≥98% (Assay)
 
Appearance:White powder.
 
Solubility:Soluble in DMSO, methanol or water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-350-257
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ALX-350-257

Product Literature References

Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs: A.R. Choi, et al.; Anticancer Res. 36, 5859 (2016), Application(s): Cell treatment with KBV20C cells, Abstract; Full Text
Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition: J.S. Lim, et al.; Anticancer Res. 36, 5063 (2016), Application(s): Cell Treatment, Abstract; Full Text
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract; Full Text
Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes: J.M. Caron & M. Herwood; Chemotherapy 53, 51 (2007), Abstract;
Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade: M. Fan, et al.; J. Biol. Chem. 275, 29980 (2000), Abstract; Full Text
Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells: E. Tashiro, et al.; Jpn. J. Cancer Res. 89, 940 (1998), Abstract;
The C terminus of beta-tubulin regulates vinblastine-induced tubulin polymerization: S.S. Rai & J. Wolff; PNAS 95, 4253 (1998), Abstract; Full Text
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998), Abstract;
Use of drugs to study role of microtubule assembly dynamics in living cells: A. Jordan & L. Wilson; Meth. Enzymol. 298, 252 (1998), Abstract;
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death: M.V. Blagosklonny, et al.; Cancer Res. 57, 130 (1997), Abstract;
Antimitotic natural products and their interactions with tubulin: Hamel, E.; Med Res Rev 16, 207 (1996), Abstract;
The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1: R.B. Tishler & D.M. Lamppu; Br. J. Cancer. Suppl. 27, S82 (1996), Abstract;
Resistance of Ehrlich tumor cells to apoptosis can be due to accumulation of heat shock proteins: V.L. Gabai, et al.; FEBS Lett. 375, 21 (1995), Abstract;
Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes: K. Tsukidate, et al.; Am. J. Pathol. 143, 918 (1993), Abstract;
Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules: R.H. Himes et al.; Pharmacol. Ther. 51, 257 (1991), Abstract;

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