Replaces Prod. #: BML-T116
Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule asembly and causes aberant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent.
Product Details
| Alternative Name: | Vincaleukoblastine . sulfate |
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| Formula: | C46H58N4O9 . H2SO4 |
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| MW: | 909.1 |
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| Source: | Semisynthetic from catharanthine or vindoline. |
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| CAS: | 143-67-9 |
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| MI: | 14: 9982 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to light yellow crystalline powder. |
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| Solubility: | Soluble in DMSO, methanol or water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells: L.N. Zebaze, et al.; Sci. Rep.
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Abstract;
Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs: A.R. Choi, et al.; Anticancer Res.
36, 5859 (2016),
Application(s): Cell treatment with KBV20C cells,
Abstract;
Full Text
Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition: J.S. Lim, et al.; Anticancer Res.
36, 5063 (2016),
Application(s): Cell Treatment,
Abstract;
Full Text
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al. ; J. Exp. Clin. Cancer Res.
34, 152 (2015),
Application(s): Cell culture,
Abstract;
Full Text
Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes: J.M. Caron & M. Herwood; Chemotherapy
53, 51 (2007),
Abstract;
Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade: M. Fan, et al.; J. Biol. Chem.
275, 29980 (2000),
Abstract;
Full Text
Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells: E. Tashiro, et al.; Jpn. J. Cancer Res.
89, 940 (1998),
Abstract;
The C terminus of beta-tubulin regulates vinblastine-induced tubulin polymerization: S.S. Rai & J. Wolff; PNAS
95, 4253 (1998),
Abstract;
Full Text
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev.
18, 259 (1998),
Abstract;
Use of drugs to study role of microtubule assembly dynamics in living cells: A. Jordan & L. Wilson; Meth. Enzymol.
298, 252 (1998),
Abstract;
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death: M.V. Blagosklonny, et al.; Cancer Res.
57, 130 (1997),
Abstract;
Antimitotic natural products and their interactions with tubulin: Hamel, E.; Med Res Rev
16, 207 (1996),
Abstract;
The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1: R.B. Tishler & D.M. Lamppu; Br. J. Cancer. Suppl.
27, S82 (1996),
Abstract;
Resistance of Ehrlich tumor cells to apoptosis can be due to accumulation of heat shock proteins: V.L. Gabai, et al.; FEBS Lett.
375, 21 (1995),
Abstract;
Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes: K. Tsukidate, et al.; Am. J. Pathol.
143, 918 (1993),
Abstract;
Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules: R.H. Himes et al.; Pharmacol. Ther.
51, 257 (1991),
Abstract;
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